Tacrolimus antimetabolite

6,7 Tacrolimus is metabolized into 8 metabolites: 13-demethyl tacrolimus, 31-demethyl tacrolimus, 15-demethyl tacrolimus, 12-hydroxy tacrolimus, 15,31-didemethyl tacrolimus, 13,31-didemethyl tacrolimus, 13,15-didemethyl tacrolimus, and a final metabolite Aug 28, 2019 · Standard maintenance therapy typically includes tacrolimus and an antimetabolite (mycophenolate mofetil or azathioprine). Use of Tacrolimus (FK506) and Antimetabolites as Immunosuppressants for Xenotransplantation Across Closely Related Rodent Species Nov 1, 2021 · Modification of the initial tacrolimus dose was required for all patients: dose reduction by 20% for low CYP3A4 expressers, a 40% increase for normal expressers and a 2

2024-03-29
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  3. Introduction
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  8. Five-year follow-up was available on 97% of patients
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  10. Quiz Instructions: Select the single best answer
  11. Hospitalized patients had their antimetabolite agent stopped
  12. However, tacrolimus also suppresses T-cell function in the skin
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  14. The safety and efficacy of tacrolimus ointment 0